"Next CAR-T Discovery" likely refers to the latest advancements or innovations in CAR-T (Chimeric Antigen Receptor T-cell) therapy research and development. CAR-T therapy is a type of cancer treatment that uses a patient’s own immune cells, which are genetically modified to better identify and attack cancer cells.



Recent advancements and discoveries in CAR-T therapy might include:



1. **Target Discovery**: Identifying new targets on cancer cells that CAR-T cells can be engineered to recognize. This is crucial for expanding CAR-T therapy beyond blood cancers to solid tumors.



2. **Improved CAR-T Cell Design**: Enhancements in the design of CARs to improve their efficacy and safety. This may include engineering improvements that enhance T-cell activation, persistence, and tumor infiltration.



3. **Overcoming Resistance**: Strategies to overcome obstacles like the tumor microenvironment, which sometimes inhibits CAR-T cell functionality.



4. **Reducing Side Effects**: Innovations aimed at reducing adverse effects such as cytokine release syndrome and neurotoxicity.



5. **Universal CAR-T Cells**: Development of “off-the-shelf” CAR-T cells that are not patient-specific, potentially making the therapy more accessible and less expensive.



6. **Combination Therapies**: Exploring synergies between CAR-T cells and other treatment modalities, such as checkpoint inhibitors or small molecules.



For specific and detailed updates, it's beneficial to look at recent scientific publications, news releases from biotechnology firms, or announcements from oncology conferences.