<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">Neurodegenerative diseases, characterized by the progressive loss of structure or function of neurons, including death of neurons, have become a significant global health concern. Conditions such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) not only diminish the quality of life for millions but also pose substantial economic burdens on healthcare systems worldwide. Understanding the pathogenesis of these diseases is crucial for developing effective therapies. Recent advancements in human induced pluripotent stem cell (iPSC)-derived neuronal cell culture models and transgenic cell line models have revolutionized neurodegenerative disease research, offering promising avenues for modeling disease mechanisms and testing therapeutic interventions.</span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="font-family: 'Times New Roman'; font-size: 10.5pt;">Human iPSC-Derived Neuronal Cell Culture Models</span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">Human iPSCs are generated by reprogramming somatic cells to a pluripotent state, allowing them to differentiate into various cell types, including neurons.</span><span class="15" style="font-family: 'Times New Roman'; color: #800080;"> iPSC-derived neuronal cultures</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> provide a physiologically relevant system that closely mimics the human nervous system's cellular and molecular characteristics. These models overcome the limitations of traditional animal models, such as species-specific differences, and primary neuronal cultures, which are challenging to obtain from patients.</span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">In recent news, a study published in Nature Neuroscience in September 2023 demonstrated the use of iPSC-derived neurons to model frontotemporal dementia (FTD). Researchers identified novel molecular mechanisms underlying FTD by observing neuronal dysfunctions in cells harboring mutations in the GRN gene. This breakthrough underscores the potential of iPSC models in uncovering disease mechanisms that can lead to targeted therapies.</span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">Creative Biolabs utilizes advanced iPSC technology to generate customized differentiated neuronal subtypes for research needs. Their expertise includes producing specialized neurons&mdash;cortical, motor, GABAergic, glutamatergic&mdash;and glial cells like microglia, astrocytes, and oligodendrocytes, thereby accelerating neurological research and drug discovery.</span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="font-family: 'Times New Roman'; font-size: 10.5pt;">Transgenic Cell Line Models</span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">Transgenic cell lines are genetically modified to express or suppress specific genes associated with neurodegenerative diseases. These models are invaluable for elucidating gene function, understanding disease mechanisms, and screening potential therapeutics. By introducing mutations linked to neurodegenerative conditions, scientists can observe the resultant cellular changes and identify key pathological processes.</span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">Creative Biolabs</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> ha</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">s</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> established a novel platform to generate various </span><span class="15" style="font-family: 'Times New Roman'; color: #800080;">transgenic cell line models</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> to serve </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">global</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> customers</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-fareast-font-family: 宋体; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;">.</span>