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  Human iPSC-Derived Neuronal Cell Culture Models (17 views)

22 May 2025 14:00

<p class="MsoNormal"><span style="font-family: 宋体; font-size: 10.5pt;"><span style="font-family: Calibri;">Human iPSC-Derived Neuronal Cell Culture Models</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">Human iPSCs are generated by reprogramming somatic cells to a pluripotent state, allowing them to differentiate into various cell types, including neurons.</span></span><span class="15" style="font-family: 宋体; color: #800080;"> <span style="font-family: Calibri;">iPSC-derived neuronal cultures</span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> <span style="font-family: Calibri;">provide a physiologically relevant system that closely mimics the human nervous system's cellular and molecular characteristics. These models overcome the limitations of traditional animal models, such as species-specific differences, and primary neuronal cultures, which are challenging to obtain from patients.</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">In recent news, a study published in Nature Neuroscience in September 2023 demonstrated the use of iPSC-derived neurons to model frontotemporal dementia (FTD). Researchers identified novel molecular mechanisms underlying FTD by observing neuronal dysfunctions in cells harboring mutations in the GRN gene. This breakthrough underscores the potential of iPSC models in uncovering disease mechanisms that can lead to targeted therapies.</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">Creative Biolabs utilizes advanced iPSC technology to generate customized differentiated neuronal subtypes for research needs. Their expertise includes producing specialized neurons</span><span style="font-family: 宋体;">&mdash;</span><span style="font-family: Calibri;">cortical, motor, GABAergic, glutamatergic</span><span style="font-family: 宋体;">&mdash;</span><span style="font-family: Calibri;">and glial cells like microglia, astrocytes, and oligodendrocytes, thereby accelerating neurological research and drug discovery.</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="font-family: 宋体; font-size: 10.5pt;"><span style="font-family: Calibri;">Transgenic Cell Line Models</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">Transgenic cell lines are genetically modified to express or suppress specific genes associated with neurodegenerative diseases. These models are invaluable for elucidating gene function, understanding disease mechanisms, and screening potential therapeutics. By introducing mutations linked to neurodegenerative conditions, scientists can observe the resultant cellular changes and identify key pathological processes.</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">Creative Biolabs</span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> <span style="font-family: Calibri;">ha</span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">s</span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> <span style="font-family: Calibri;">established a novel platform to generate various </span></span><span class="15" style="font-family: 宋体; color: #800080;"><span style="font-family: Calibri;">transgenic cell line models</span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> <span style="font-family: Calibri;">to serve </span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">global</span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> <span style="font-family: Calibri;">customers</span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">.</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="font-family: 宋体; font-size: 10.5pt;"><span style="font-family: Calibri;">Neurodegenerative Disease Modeling Using Advanced Cellular Systems</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">Combining iPSC-derived neuronal cells with transgenic technologies has further enhanced </span></span><span class="15" style="font-family: 宋体; color: #800080;"><span style="font-family: Calibri;">neurodegenerative </span></span><span class="15" style="font-family: 宋体; color: #800080;"><span style="font-family: Calibri;">disease modeling</span></span><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">. Researchers can introduce specific genetic mutations into iPSC lines, creating isogenic pairs that differ only at the mutation of interest. This approach allows for precise studies on the effect of genetic variations on neuronal function.</span></span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"> </span>

<p class="MsoNormal"><span style="mso-spacerun: 'yes'; font-family: 宋体; mso-ascii-font-family: Calibri; mso-hansi-font-family: Calibri; mso-bidi-font-family: 'Times New Roman'; font-size: 10.5000pt; mso-font-kerning: 1.0000pt;"><span style="font-family: Calibri;">Advanced disease models have been developed to study the interactions between different cell types in the nervous system. Co-culture systems involving neurons and glial cells derived from iPSCs enable the investigation of neuroinflammatory processes, which are increasingly recognized as significant contributors to neurodegeneration.</span></span>

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